Nucleic Acids and the Genetic Material Problem Set

Nucleic Acids and the Genetic Material Problem Set 1

In this diagram of the process of DNA replication at a replication fork, the black boxes labeled D and E are:

DNA template with synthesis of a new strand in the 5' to 3' direction.
The 5' triphosphate can only be added to a free 3'OH of deoxyribose.
The two antiparallel strands are replicated simultaneously in both directions.
RNA primers are used to initiate a new strand.
The parent strand at the 3' end of the template determines the daughter or leading strand in continuous replication.
The parent strand at the 5' end of the template produces the lagging strand as short pieces of DNA (100-200 nucleotides in eukaryotes and longer in prokaryotes).
The lagging strand fragments are called Okazaki fragments after their discoverer, Reiji Okazaki.
The RNA primers are removed by DNA polymerase and the fragments are joined by DNA ligase.

The Biology Project
University of Arizona
Thursday, October 3, 1996
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