Regulation of Carbohydrate Metabolism Problem Set

Question 3: PFK-1 Regulation in Liver

Given that the phosphofructokinase-1 (PFK-1) enzyme is regulated by insulin, but not via (de)phosphorylation, how is this regulation accomplished?

A.	Via increased transcription of the gene encoding this enzyme
B.	By recruitment of pre-existing enzyme from the Golgi
C.	Via allosteric regulation by fructose-2,6-bisphosphate
D.	Activation by association with IRS-1
E.	An inhibitory subunit of the enzyme dissociates after binding cAMP

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