B12/Folate Problem set
Question 1: "Folate trapping" in a vitamin B12 deficiency
Insufficient Vitamin B12 often creates an apparent folate deficiency by trapping which folate intermediate?
A. folic acid B. dihydrofolate (DHF) C. tetrahydrofolate (THF) D. N5-methyl THF The suggested mnemonic to remember this is that, in the intersection between the folate and B12 pathways, it is methyl-folate that donates the methyl group to B12 to make methyl-B12. Of course, if there is no B12 around, this cannot happen, and the folate becomes trapped. The next question asks a bit more about methyl-B12...E. N10-formyl THF
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Department of Biochemistry and Molecular Biophysics
The University of Arizona
January 31, 2000
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