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Regulation of Carbohydrate Metabolism Problem Set

Question 1: Liver Enzymes Affected by Insulin

Insulin facilitates energy storage in liver. Which enzymes of carbohydrate metabolism are coordinately regulated in liver in response to insulin signaling?

1. Glycogen synthase

2. Glycogen phosphorylase

3. Phosphofructokinase-1 (PFK-1)

4. Phosphofructokinase-2 (PFK-2)

5. Pyruvate kinase

Tutorial

Six enzymes shown in red (including all five listed in question) are affected by insulin, via three different mechanisms. All but glycogen phosphorylase are stimulated. However, note that PFK-2 is one activity of a bifunctional enzyme - the other "half" of this two-headed beast will come up later in this tutorial.

Problem 1 | Answer | Problem 2

Vocabulary

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